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In persons aged 60 years and over with isolated sytolic hypertyension, antihypertensive stepped-care drug treatment with low-dose chlorthalidone as step 1 medication reduced the incidence of total stroke by 36%,with 5- year absolute benefit of 30 events per 1000 participants.Major cardiovascular events were reduced,with 5-year absolute benefit of 55 events per 1000. |
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